The Triad Hsp60-miRNAs-Extracellular Vesicles in Brain Tumors: Assessing Its Components for Understanding Tumorigenesis and Monitoring Patients

Brain tumors have a poor prognosis and progress must be made for developing efficacious treatments, but this to occur their biology interaction with the host elucidated beyond current knowledge. What has been learned from other may applied study brain tumors, example, role of Hsp60, miRNAs, extracellular vesicles (EVs) in mechanisms cell proliferation dissemination, resistance immune attack anticancer drugs. It established that Hsp60 increases cancer cells, which it occurs not only mitochondria also cytosol plasma-cell membrane is released EVs into space circulation. There evidence suggesting these interact cells near far original an impact on functions target cell. assumed crosstalk between favors carcinogenesis various ways. We, therefore, propose triad Hsp60-related miRNAs-EVs standardized methods purpose. These revealed related miRNAs increase patients’ blood manner reflects disease status. The means are now available monitor tumor patients by measuring dissect its effects vitro, experimental models vivo.